My Apophysis mucked up, boo hoo. Everytime I opened it up I got an error (2 errors in fact) and I couldn't do anything in it.
Re-install, nuffin. Un-install, registry clean, re-install, nuffin.
In the end had to do a System Restore, turns out a Widows Vista Upate (dunno which one yet, have not tried to put them back 1 by 1) caused a conflict.

2 days of head banging, which to be fair I miss from my moshing days anyway lol.